Host-Microbiome Co-Metabolism
The gut microbiota is an important metabolic "organ" within mammalian organisms, affecting the host's overall metabolism. Host metabolism is influenced by both its own genes and the gut microbiota genes, and there is a process of "co-metabolism" between the host and microbiota. We can test the host-symbiotic gut microbiota metabolites in urine or feces, including phenylalanine metabolism, fatty acid metabolism, carbohydrate metabolism, purine and pyrimidine metabolism, etc. They are mainly classified according to the chemical structure types, including phenols, indoles, carbohydrates, amino acids, fatty acids, etc.
Platform and Strategy
Platform and Strategy LC-MS/MS
Technical workflow
Bioinformatics analysis pipeline and partial results presentation
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生物信息分析流程图
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| 代谢物分类饼图 | 差异代谢物相关性热图 | 差异代谢物层次聚类分析 |
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| 差异代谢物富集代谢通路气泡图 | 正交偏最小二乘法判别分析 | 差异代谢物火山图 |
Application areas
1、Medical field: Metabolomics is used in studying the complex metabolic systems associated with the gut microbiota-host interaction. As a relatively comprehensive, continuous, and non-invasive analytical approach, metabolomics objectively detects the metabolic components and concentration changes of gut microbiota, revealing the metabolic status of the gut microbiota and providing important information for investigating mechanisms underlying disease occurrence, development, and prognosis.
2、Livestock industry: Through metabolomics studies of the metabolic system between animals and gut microbiota, it elucidates the characteristics of metabolic changes caused by factors such as nutrition supply, feeding conditions and methods, different feeds, and veterinary drugs. It reveals the mechanisms of their actions in animals, contributing to improving production efficiency in the livestock industry and ensuring its safety and stable development. It is mainly applied in scientific breeding, disease prevention and treatment, and developmental research.